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covid-19

3 papers tagged “covid-19

EconomicsThe Review of Financial Studies · Nov 2021 Open access

The Macroeconomics of Epidemics

Martin S. Eichenbaum, Sergio Rebelo and Mathias Trabandt

The authors extend the canonical SIR epidemiological model by embedding it in a macroeconomic framework where people's consumption and labor decisions affect the spread of infection. They show that the epidemic causes a sharp recession because infected and susceptible agents cut activity to reduce contagion. A key tension emerges: the competitive equilibrium worsens the epidemic because individuals do not internalize the infection externality, and well-designed containment policy can mitigate the death toll though it deepens the short-run economic contraction.

MedicineNew England Journal of Medicine · Dec 2020 Open access

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Fernando P. Polack, Stephen J. Thomas, Nicholas Kitchin, Judith Absalon, Alejandra Gurtman, Stephen Lockhart, et al.

This multinational, randomized, placebo-controlled phase 2/3 trial evaluated the safety and efficacy of two 30-µg doses of the BNT162b2 lipid-nanoparticle mRNA vaccine, given 21 days apart, in 43,548 participants 16 years of age or older. Among those without prior SARS-CoV-2 infection, the vaccine conferred 95% protection against laboratory-confirmed Covid-19 beginning at least 7 days after the second dose. The safety profile over a median of about two months was characterized by short-lived, mostly mild-to-moderate reactions, with a low incidence of serious adverse events comparable to placebo.

BiologyNature · Apr 2020 Open access

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon, Gwendolyn M. Jang and Mehdi Bouhaddou

The authors expressed 26 of the 29 SARS-CoV-2 proteins in human cells and used affinity-purification mass spectrometry to map 332 high-confidence virus-human protein-protein interactions. They then identified 69 existing drugs and compounds that target the human proteins in this interactome and tested several for antiviral activity. Two pharmacological classes (mRNA translation inhibitors and Sigma1/Sigma2 receptor regulators) showed antiviral effects, providing candidate therapeutics for repurposing.