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t2t

1 paper tagged “t2t

BiologyScience · Apr 2022 Open access

The complete sequence of a human genome

Sergey Nurk, Sergey Koren and Adam M. Phillippy

The Telomere-to-Telomere (T2T) Consortium reports T2T-CHM13, the first essentially gapless assembly of a human genome (all chromosomes except Y), totaling about 3.055 billion base pairs. The assembly resolves previously unfinished heterochromatic and repetitive regions, including centromeric satellite arrays, segmental duplications, and the short arms of the acrocentric chromosomes. It adds nearly 200 million base pairs of new sequence and corrects errors in prior reference assemblies.