Biomolecular condensates: organizers of cellular biochemistry
This review synthesizes how cells organize biochemistry into membraneless compartments termed biomolecular condensates, which form largely through liquid-liquid phase separation driven by multivalent macromolecular interactions. It describes the physical principles of condensate formation, their compositions, and how they concentrate or sequester molecules to regulate cellular processes. The authors discuss functional roles and the emerging links between aberrant condensate behavior and disease.