A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
The authors expressed 26 of the 29 SARS-CoV-2 proteins in human cells and used affinity-purification mass spectrometry to map 332 high-confidence virus-human protein-protein interactions. They then identified 69 existing drugs and compounds that target the human proteins in this interactome and tested several for antiviral activity. Two pharmacological classes (mRNA translation inhibitors and Sigma1/Sigma2 receptor regulators) showed antiviral effects, providing candidate therapeutics for repurposing.