Keyword

discovery

2 papers tagged “discovery”

MedicineScience · May 1983

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

Françoise Barré-Sinoussi, Jean-Claude Chermann, F. Rey, M. T. Nugeyre, S. Chamaret and Luc Montagnier

The authors reported the isolation of a novel retrovirus from a lymph-node biopsy of a patient with lymphadenopathy considered at risk for AIDS. The virus exhibited magnesium-dependent reverse transcriptase activity, budded as a type-C particle, and showed tropism for T lymphocytes, but was antigenically and biologically distinct from the known human T-cell leukemia viruses (HTLV-I/II). This agent—later designated lymphadenopathy-associated virus (LAV) and subsequently recognized as HIV—was proposed as a candidate cause of AIDS.

hiv aids retrovirus virology

MedicineBritish Journal of Experimental Pathology · Jun 1929 Open access

On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. influenzæ

Alexander Fleming

Fleming reported that a mould of the genus Penicillium, which had contaminated a culture plate, produced a diffusible substance—which he named 'penicillin'—that inhibited the growth of many common pathogenic bacteria. He characterized the antibacterial spectrum and potency of the crude culture filtrate, showing it was strongly active against Gram-positive organisms (such as staphylococci and streptococci) while sparing certain Gram-negative bacilli. He proposed using the agent both as a selective culture medium for isolating Bacillus influenzae and as a relatively non-toxic antiseptic.

penicillin antibiotics microbiology discovery