Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

Nicholas Schaum, Stephen R. Quake, Tony Wyss-Coray · Authored by the Tabula Muris Consortium; senior/corresponding authors include Stephen R. Quake and Tony Wyss-Coray (with Nicholas Schaum, Jim Karkanias, Norma F. Neff, Andrew P. May, and many others).

Published 3 October 2018 · Nature · Journal article

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Summary

The Tabula Muris Consortium generated a compendium of single-cell transcriptome data spanning 20 organs and tissues from the mouse Mus musculus. Both droplet-based (10x) and FACS-sorted plate-based (Smart-seq2) methods were used to profile cells, enabling characterization of cell types across the organism. The resource provides a cross-tissue reference for defining and comparing mouse cell populations.

Key findings

Created a multi-organ single-cell transcriptomic atlas covering 20 mouse organs.
Combined droplet (10x) and full-length plate-based (Smart-seq2) sequencing for complementary coverage.
Enabled identification and comparison of cell types and gene expression across tissues.

Subjects & keywords

Biology & Genetics single-cell rna-seq mouse atlas tabula muris cell types transcriptomics

Cite this paper

APA

Nicholas Schaum, Stephen R. Quake, & Tony Wyss-Coray [Authored by the Tabula Muris Consortium; senior/corresponding authors include Stephen R. Quake and Tony Wyss-Coray (with Nicholas Schaum, Jim Karkanias, Norma F. Neff, Andrew P. May, and many others).] (2018). Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. https://doi.org/10.1038/s41586-018-0590-4

BibTeX

@article{schaum2018singlecell,
  author    = {Nicholas Schaum and Stephen R. Quake and Tony Wyss-Coray and {Authored by the Tabula Muris Consortium; senior/corresponding authors include Stephen R. Quake and Tony Wyss-Coray (with Nicholas Schaum, Jim Karkanias, Norma F. Neff, Andrew P. May, and many others).}},
  title     = {Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris},
  journal   = {Nature},
  year      = {2018},
  doi       = {10.1038/s41586-018-0590-4},
  url       = {https://doi.org/10.1038/s41586-018-0590-4}
}

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